منابع مشابه
Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation
Centrosome overduplication promotes mitotic abnormalities, invasion and tumorigenesis. Cells regulate the number of centrosomes by limiting centriole duplication to once per cell cycle. The orthogonal orientation between a mother and a daughter centriole, established at the time of centriole duplication, is thought to block further duplication of the mother centriole. Loss of orthogonal orienta...
متن کاملThe de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly/maturation
t has been reported that nontransformed mammalian cells become arrested during G 1 in the absence of centrioles (Hinchcliffe, E., F. Miller, M. Cham, A. Khodjakov, and G. Sluder. 2001. Science . 291:1547–1550). Here, we show that removal of resident centrioles (by laser ablation or needle microsurgery) does not impede cell cycle progression in HeLa cells. HeLa cells born without centrosomes, la...
متن کاملA Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila
Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a microscopy-based genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins required for centriole duplication and mitotic PCM recruitment. We analysed 92% of the Drosophila genome (13,059 genes) and identified 32 genes involved in centrosome fun...
متن کاملIntroduction to Motherhood
It is unfortunate that Roddis presents Lind as a personage and tells us so little of the person, or rather of the personality, with the drives and motivations which made for such a wide spectrum of researches and activities. But despite the rather too academic and impersonal handling, the story of James Lind offers interesting and profitable reading.
متن کاملFrom motherhood to maternal subjectivity
In moving from concepts of motherhood and mothers to a theorisation of maternal subjectivity that emphasises unconscious intersubjectivity, this paper casts light on the following questions: ⇒ What is meant by maternal and who qualifies? ⇒ Do gender and sex of parents and carers make any systematic difference to an infant, child or adolescent’s experience of parenting and their own capacity to ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2015
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2015.12